Name: S. S. S. B. D. Preethi Soysa

Official Address: Department of Biochemistry and Molecular Biology, Faculty   of Medicine Colombo, Sri Lanka

email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Contact No.    94-011-2697485 (official)

Educational qualifications:

B.Sc in Applied Sciences (1979), University of Sri Jayawardenapura, Sri Lanka

M.Sc in Biochemistry (1982), University of Colombo, Sri Lanka

Ph. D in Biochemistry (1996), University of Colombo, Sri Lanka

 Field of Study for Ph.D

Drug Metabolism and Interactions

 Ongoing/Completed Research

Studies on

  • Abnormal Urinary metabolites in Autism Children
  • Cytotoxicity and Apoptosis Studies with Tea, Herbal Teas and Aurvedic Drug Preparations and plants,
  • Iron absorption in Different Rice Varieties
  • Antioxidant activity of plants and biological fluids
  • Metabolism of Tea Polyphenols,
  • Drug interactions with Food/Herbs using liver slices
  • Pharmcokinetic analysis of drugs
  • Paracetamol levels in blood under different setups

 Postgraduate research supervision

M.Sc in Biochemistry and Molecular Biology, Dept of Biochemistry and Molecular Biology, Faculty of Medicine, Colombo      

  • Effects of herbal plant extracts on Paracetamol metabolism and liver toxicity using porcine liver slices (2012)
  • Evaluation of phytochemical composition, antioxidant activity and anticancer activity of Semecarpus parvifolia leaf extracts- DDPP Jayarathna (2012)
  • Effects of ayurvedic herbal decoction “pas panguwa” on Paracetamol pharmacokinetics (2010)
  • Apoptosis studies with  Flueggea leucopyrus (2010) Irushi de Silva
  • Apoptosis studies A decoction composed of Adenanthera pavonina L. and Thespesia populnea L.(2010) Kalhari Silva
  • Analysis of children with autism and laearning difficulties:Optimization of polymerase chain reaction of CYP271B1 gene and analysis of urinary metabolites of purine metabolism and sulphoconjugation (2010) MKAN Wijemanne
  • Apoptosis studies with a selected decoction used in cancer therapy  – Priyantha Ihalagamage (2008)
  • Apoptosis studies with tea constituents (2005) - Subashini Jayawardena
  • Preliminary Studies on absorption and elimination of Tea Polyphenols in Rats (2000) - WAIC Silva

 M.Sc in Analytical Chemistry, Faculty of Science, University of Colombo

  • Apoptosis studies with herbal extracts - Namal Perera (2006)

M.Sc in Clinical Biochemistry, Postgraduate Institute of Science, Peradeniya

         Screening of Camptothecin in plants belong to Family Rubiaceae-Jayaraj J Thusyanathan (2012)

 M.Phil dgree, University of Colombo, Sri Lanka

  • Biological activities of selected fungi
  • Anti cancer activity of selected medicinal plants  in Sri Lanka
  • Cytotoxicity studies with Different extract of Pleurotus Cystidiosnus.- Enoka Manikpurage (2006/2007)
  • Anti cancer activity of tea products manufactured  in Sri Lanka
  • Paracetamol Analysis- The economical burden of current management of patients with acute paracetamol poisoning in tertiary care hospital of Sri Lanka- Ganga Senaratne (2006)

 M.Sc. in Food Science, Faculty of Applied Sciences, University of    Sri Jayawaredanapura, Nugegoda, Sri Lanka

Co-supervisor

  • Estimation of Vitamin A levels in Milk During Storage  -  MW Galahitiyawa

 

Research Grants Awarded

  • National Research Council (2000), Sri Lanka
  • National Science Foundation (2006), Sri Lanka
  • Under IRQUE project (2006), Sri Lanka
  • Under IRQUE project (2008), Sri Lanka (Co investigator)
  • University of Colombo (2012)

 

Laboratory Planning and Development

  • Establishment of a cell culture laboratory for Apoptosis Studies
  • Establishment of laboratory for drug analysis

International Fellowships/Awards

 Fellowship under Scientist Exchange Programme by Science and Technology Agency, Japan (1996)

 Silver medal - L.I.K Silva  and S.S.S.B.D.P. Soysa,  "Antiproliferative activity and induction of apoptosis by a decoction prepared from Adenanthera pavonina and Thespesia populnea"  "International Conference on Stem Cells and Cancer (ICSCC-2010): Proliferation, Differentiation and Apoptosis", 11-14 December,2010 Pune, India.

 Research Publications

  1. S.M.D.K. Ganga Senarathna, Shalini S. Ranganathan, Nick Buckley, S.S.S.B.D. Preethi Soysa, B. M. Rohini Fernandopulle. A quick inexpensive laboratory method in acute paracetamol poisoning could improve risk assessment, management and resource utilization. Indian Journal of Pharmacology 2012;44 (4): 463-468.
  2. Inoka P. Menikpurage, S.S.S.B.D.P. Soysa, D.T.U. Abeytunga, Antioxidant activity and cytotoxicity of the edible mushroom, Pleurotus cystidiosus against Hep-2 carcinoma cells J.Natn.Sci.Foundation Sri Lanka 2012 40(2):13-20
  3. Indeewari Kalhari Silva and Preethi Soysa,  Evaluation of  Phytochemical Composition and Antioxidant Capacity of A Decoction Containing Adenanthera pavonina. L and Thespesia Pharmacogn Mag. 2011 Jul-Sep; 7(27): 193–199.
  4. M.G.A.N.Perera, S.S.SB.D.P Soysa, D.T.U Abeytunga, R Ramesh  (2008), Antioxidant cytotoxic properties of three traditional decoctions used for the treatment of cancer in Sri Lanka.  Pharmacognosy Magazine Vol 4, 172-181.
  5. Soysa SSSBDP and Karunanayake EH (1985) Effects of tea brew in urinary excretion and tissue distribution of 14C-caffeine in the rat. Journal of National Science Council 13(1), p 29-44.
  6. Soysa Preethi and Kolombage Saman Rapid HPLC/UV method for analysis of urinary and plasma/serum paracetamol concentrations  J.Natn.Sci.Foundation Sri Lanka 2010 38 (2):131-137

 Communications with Published Abstracts

  1. DDPP Jayarathna and SSSBDP Soysa. Total phenolic content and antioxidant activity of the water extract of Semecarpus parvifolia (Heen Badulla). Proceedings of the 68th Annual Sessions of Sri Lanka Association for Advancement of Science.2012, p66.
  2. M.K. Nimanthi W. Ekanayake.  Hemamali Perera, S.S.S.B.D. Preethi  Soysa, Sulochana  Wijesundera Abnormal Purine Metabolism in Children with Autism. 35th Australian Association for Cognitive and Behavior Therapy Conference, Gold coast, QLD, Australia,17th-19th  October 2012.
  3. Siriwardena HVYD, Ranasinghe GSP, Weerasinghe S, Soysa SSBDP, Karunaweera ND. A study on the visceralization potential of Cutaneous Leishmanaiasis in Sri Lanka. Annual Research Symposium 2012, University of Colombo. 16th and 17th August 2012.
  4. Wijayabandara M.D.J, Mendis B.M.M.J, Iqbal Choudhary M, Soysa S.S.S.B.D.P, Ahmed Mesaik M. Characterization of biological activity and the major active constituent of Flueggea leucopyrus Willd. 13th International Congress of the Society for Ethnopharmacology, September 2-6, 2012
    Graz, Austria
  5. N Prasanna, LV Goonaratne, BCM Wimalachandra, HMJP Herath, MD Perera, DP Suriyamudalige, KSJ Kolambage, SSBDP Soysa, PC Rodrigo, S Rajapakse. Aspirin resistance among Sri Lankan patients; Sri Lanka Medical Association 125th Anniversary International Medical Congress, 2 to 6 July 2012
  6. M. K. Nimanthi W. Ekanayake, S. S. S. B. D. Preethi Soysa, Hemamali Perera. Analysis of sulphoconjugation in children with autism and learning difficulties 12th International Child Neurology Congress and 11th Asian and Oceanian Congress of Child Neurology. May 27th-1st June 2012.
  7. M.G.P Dassanayake, S.S.S.B.D.P Soysa and P.L Hettiarachhi Antioxidnat activity and the distribution of phenolic compounds in different parts of the tea plant (Camellia sinensis L). International Conference on Chemical Sciences Colombo, Sri Lanka June 19th -24th 2012
  8. Irushi De Silva, Preethi Soysa and Jayantha Wijayabandara. Cytotoxic activity of the aqueous extract of Fluggea leucopyrus  (Katupila) leaves against HEp-2 cells. 3rd International Conference on Medicinal Plants and Herbal Products 2011 Sri  Lanka p 106-107.
  9. Preethi Soysa, Tharaka Bandara, Randeevari Gunarathne, Priyanga Ranasinghe, Sashimali Wickramasinghe. 'Effect of tea constituents on paracetamol pharmacokinetics in healthy volunteers'  Asian Federation for Pharmaceutical Science Conference 2011. Kuala Lampur Malaysia
  10. MK Nimanthi W Ekanayake, SSBDP Soysa Development and Validation of High Performance Liquid Chromatography/ UV Method for Simultaneous Determination of Urinary Uric Acid, Hypoxanthine and Creatinine. Pittcon Conference and Expo 2011 Atlanta
  11. Hemamali Perera, Preethi Soysa, Sulochana Wijesundera, Nimanthi Wijemanne. Analysis of Urinary Purine Metabolites in Children with  Autism. Sri Lanka College of Psychiatrists. Annual Academic Conference, Sri Lanka 2011. Free Paper
  12. L.I.K Silva  and S.S.S.B.D.P. Soysa,  "Antiproliferative activity and induction of apoptosis by a decoction prepared from Adenanthera pavonina and Thespesia populnea"  "International Conference on Stem Cells and Cancer (ICSCC-2010): Proliferation, Differentiation and Apoptosis", 11-14 December,2010 Pune, India.
  13. L.I.K Silva, S.S.S.B.D.P. Soysa. Antioxidant and cytotoxic activities of a decoction prepared from Adenanthera pavonina (madatiya) and Thespesia populnea (gansuriya).  Proceedings of the 66th Annual Sessions of Sri Lanka Association for Advancement of Science.2010, p76.
  14. A.A.S.Adikaryand S.S.S.B.D.P. Soysa. Comparison of cell viability of black, green and white tea (Camellia sinensis) manufactured in Sri Lanka. Proceedings of the 66th Annual Sessions of Sri Lanka Association for Advancement of Science 2010, p99.
  15. Adikary A.A.S and Soysa S.S.S.B.D.P. High grown Sri Lankan black tea extract without the polyphenolic components does not show cytotoxic and antioxidant activities. Fourth Global Summit on Medicinal Aromatic Plants; Sarawak. Kuching Malaysia.1st-5th December 2009
  16. Kulathunga Nilukshi, Pathirana W and  Soysa S.S.S.B.D.P. (2009) Annual Academic Sessions of Open University Sri Lanka 118.
  17. P.A.R Senali and  Soysa S.S.S.B.D.P (2009) Absorption and serum protein binding of tea polyphenols in rats, after administration of caffeine with tea extract. Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science.
  18. Rathnayaka R.M.B.I. and Soysa S.S.S.B.D.P. (2009) Absorption of polyphenols and the effect on serum antioxidant activity after consumption of coriander (Coriandrum sativum), seed extract Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science,.
  19. Adikary A.A.S and Soysa S.S.S.B.D.P (2009 ) Comparison of the antioxidant activity of Black, Green and White Tea Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science 
  20. Samaranayake NR , Soysa SSSBDP (2008), Kariyawasam H,  Important issues in pregnant epileptics, Annual Session of Institiute of Biology
  21. Ihalagamage, P.J and Soysa S.S.SB.D.P. Study on antiproliferative activity of a selected decoction used for cancer therapy in Sri Lanka 1st International Conference in Holistic Medicine-Kottayam, Kerala, India. August 21-23, 2008.
  22. B.M.MJ.Mendis, M.D.J Wijebandara and S.S.S.B.D.P Soysa Characterization of Biological Activity of Fleuggea leucopyrus Wild (Katupila).Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science.
  23. Manikpurage, I.P, Abeythunga D.T.U and S.S.S.B.D.P Soysa Anti-oxidant activity of Pleurotus cystidiosus . Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science.
  24. De Silva Savan Kalna, Ariyadasa Hirantha and Soysa S.S.S B.D.P,Study on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity in relation to the phenolic and gallic acid content in four medicinal plants used for cancer therapy in Sri Lanka Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science
  25. M.G.A.N. Perera S,S.S.S.B.D P. Soysa, A.A.S. Adikary, D.T.U. Abeytunga  (2007) Society for integrative oncology, Fourth International Conference Expanding Horizons in Collaborative Cancer Care, San Francisco, California, November 15-17, 2007. Total phenolic and gallic acid content strongly associate with antioxidant and cytotoxic properties of three traditional decoctions used for treatment of cancer in Sri Lanka 
  26. Widyalankara Anuradhi, Soysa SSSBDP (2007). Drug interactions, The effect of Corriander extract on paracetamol pharmacokinetics in rats. Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science, 62
  27. Senarathna SMDKG, S Sri Ranganathan, P Soysa,BMR Fernandopulle (2007) Colorimetric Technique: a cheaper method to assess the risk of hepatotoxicity in patients with acute paracetamol poisoning 6th Asia Pacific Medical Copngress, Bangkok
  28. SMDKG Senarathna, S Sriranganathan, P Soysa, , BMR Fernandopulle (2007). Cost current management of acute paracetamol poisioning. Annual Session of  Sri Lanka Medical Association
  29. SMDKG Senarathna, S Sri Ranganathan, P Soysa, N Freemantle, BMR Fernandopulle (2007). History of  ingested dose and plasma paracetamol levels in for the risk assessment in a acute paracetamol poisioning in resourced limited setting. International conference in Toxicology -
  30. Senarathna SMDKG, Sri Ranganathan S, Soysa P, Fernadopulle R. (2006). The economical burden of current management of patients with acute paracetamol poisioning in a tertiary care hospital of Sri Lanka. Presented in Annual Conference  for South Asian Clinical Toxicological Research Collaboration  
  31. Wijayawardena MAA, Soysa SSSBDP (2005). Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science, 60 ,74-75. The effect of cammellia sinensis  (tea ) on paracetamol pharmacokinetics in rats.
  32. Abhayaruwan MMGNK, Soysa SSSBDP and Andrahennadi TP (2004) Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science; 59,  227. Pharmacokintics of caffeine in rats following administration of caffeine, caffeine with tea infusion and caffeine with tea cream.
  33. Soysa SSSBDP, Udugama MIK (2002). Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science 58 265 A simple colorimetric method for estimation of polyphenols present in tea – Comparative study with vanillin reagent.
  34. Soysa SSSBDP, Udugama MJK, Andrahennadi TP (2002). Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science 58, 266. The effect of tea and polyphenol free tea extracts on protein binding of caffeine in rats.
  35. Fernandopulle M, Fernandopulle BMR, SriRanganathan S, Sathiadas MG, Soysa SSSBDP, Thalwattegedara C Jamburuthugoda V, (2001). Annual Sessions of Sri Lanka Medical Association Abstracts p55, Paracetamol toxicity in children
  36. Galahitiyawa MW, Jayawardena MIFP and and Soysa P (2001). Abstracts Annual Academic sessions, p 22. Faculty of Medicine, University of Sri Jayawardenapura. Estimation of Vitamin A content in pasteurized milk during storage.
  37. Silva WAIC, Soysa SSSBDP, Karunanayake EH (2000).. Preliminary studies on absorption and elimination of (-) epigallocatechin gallate in rats. Proceeding of the Annual Sessions of Sri Lanka Association for Advancement of Science, 56, p 261
  38. Silva WAIC, Soysa SSSBDP, Karunanayake EH (2000). Determination of (-)  - epigallocatechin -3-gallate in biological fluids. Proceeding of the Annual Sessions of Sri Lanka Association Advancement of Science, 56, p267,
  39. Soysa SSSBDP, Karunanayake EH (1998). Absorption and demethylation of caffeine in rat following administration of caffeine, caffeine with tea and caffeine with polyphenol free tea infusions. Proceeding of the Annual Sessions of Sri Lanka Association for Advancement of Science, 54, p 36.
  40. Soysa SSSBDP, Karunanayake EH (1992). Effect of tea on caffeine metabolism. Proceeding of the Annual Sessions of Sri Lanka Association for Advancement of Science, 48, p 07.
  41. Soysa SSSBDP and Karunanayake EH (1991). Study of the distribution of caffeine and its metabolites in tissue sub-cellular fractions. Proceeding of the Annual Sessions of Sri Lanka Association for Advancement of Science, 47, p 05.
  42. Soysa SSSBDP and Karunanayake EH (1984), Further studies on interactions of tea on caffeiene metabolism. Proceeding of the Annual Sessions of Sri Lanka Association for Advancement of Science, 40, p 01
  43. Karunanayake EH, Jayawardena SSSBDP and Weerasena HR (1984). A reverse phase HPLC procedure for the measurement of theophylline and caffeine in biological fluids. Proceeding of the Annual Sessions of Institute of Chemistry, Sri Lanka, p 07-08.
  44. Karunanayake EH, Jayawardena SSSBDP and Roberts G (1983), Effects of tea on tissue distribution of caffeine. Proceeding of the Annual Sessions of Sri Lanka Association for Advancement of Science, 39, p 03-04.
  45. Karunanayake EH, Jayawardena SSSBDP and Roberts G (1983),  Effects of tea on absorption and excretion of caffeine. Proceeding of the Annual Sessions of Sri Lanka Association for Advancement of Science, 39, p 03.
  46. Karunanayake EH, Jayawardena SSSBDP (1982). A study of the effect of tea on caffeine metabolism. Proceeding of the Annual Sessions of Institute of Chemistry, Sri Lanka.   p 7-8.

 Contact Information

email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Official Address: Department of Biochemistry and Molecular Biology, Faculty   of Medicine Colombo, Sri Lanka

T.P No: 2697947