Dr.S L. PATHIRANA

B.Sc.(Hons)PhD (Colombo)

 Senior Research Officer

 CONTACT INFORMATION

PHONE: 00-94-11–2695300 Ext.182

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EDUCATIONAL QUALIFICATIONS:

  • B.Sc. (Hons) (Botany, Chemistry and Zoology and specialized in Zoology) - University of Kelaniya, Sri Lanka; January 1991.
  • Ph. D. on Parasitology/ Immunology - University of Colombo, Sri Lanka; October 1998.

PROFESSIONAL QUALIFICATIONS:

  • Post-doctoral Research Training, Division of Biological Sciences, Institute of Cell Animal and Population Biology, University of Edinburgh, United Kingdom for one-year period, from September 1998 till August 1999.

POSTS HELD/ DUTIES AND RESPONSIBILITIES

  • Overall Coordinator of the University Development Grant (UDG) for the University of Colombo under the World Bank Funded Higher Education for the Twenty first Century (HETC) project from April 1, 2011 to date.
  • Deputy Coordinator of the HETC-QIG window 3 project for the promotion of postgraduate research of the Faculty of Medicine, University of Colombo
  • Senior Research Officer of the Malaria Research Unit, Dept of Parsitology, Faculty of Medicine, University of Colombo since April 2008.
  • Research Officer of the Malaria Research Unit, Dept of Parsitology, Faculty of Medicine, University of Colombo since April 2002 till March 2008
  • Coordinator of the World Bank funded IRQUE-QEF (improving relevance and quality of undergraduate education – Quality Enhancement Fund) project for the MBBS Study Programme, Faculty of Medicine, University of Colombo from November 2006 till June 2008. 
  • Deputy Coordinator – IRQUE-QEF project from January 2006 till November 2006 and from June 2008 till 2010 and handled all the procurements.  
  • Member of the Research and Higher Degree Committee of the Faculty of Medicine from 2009 till 2012.
  • Coordinator of the Malaria Research Unit (MRU), Department of Parasitology, Faculty of Medicine, University of Colombo from June 16, 2004 till end of February 2005.  

RESEARCH PROJECTS AWARDED

  • Principal Investigator of the collaborative research project “P.cyno cross” with Prof Richard Culleton, University of Nagasaki.  Period is from March to September 2014.  The grant amount is Rs 419,190.51.
  • Principal Investigator of the postgraduate training research project “Longitudinal malaria, health and human development survey in the Kataragama region of Sri Lanka” From the World Bank HETC-QIG-W3 project.  Project period from 2012-2015.  Grant amount is Rs 1,500,000.00 and will be carried out in Hambantota and Moneragala districts.
  • Principal Investigator of the research project “Study on measles, mumps and rubella antibody status in mothers and their new born babies in Colombo District” granted by the Medical Research Institute.  Project period from 2012-2014.  Grant amount is Rs 900,000.00 and is being conducted in Colombo District.
  • Principal Investigator of the three -year research project titled  “Studies on identification of genes coding strain-specific protective immunity to Plasmodium infection.”, awarded by the National Research Council of Sri Lanka. Project period from 2006-2008.  Gant amount was Rs 1,900,000.00 and was conducted in Kataragama and Colombo.
  • Principal Investigator of the two-year re-entry project granted by World Health Organization/TDR, in year 2001, under the title “Studies on “strain”-specific protective immunity to Plasmodium cynomolgi infection” ID A00577.  Project period from 2002-2004.  Grant amont was USD 40,000.00 and was conducted in Colombo, Anuradhapura and Kataragama areas.
  • Principal Investigator of the two-year research project titled  “Studies on association between the sporozoite inoculum and relapse rate using P. cynomolgi/Toque monkey system”, awarded by the National Science Foundation of Sri Lanka. Project period from 2005-2007.  Grant was Rs 1,300,000.00 and was conducted in Colombo and Kataragama areas.
  • Research Training scholarship (for one year) from the WHO/TDR in 1998 for the Molecular Biology training at University of Edinburgh, UK.  Grant was GBP 8,400.00 and training was obtained in Edinburgh UK.
  • IRQUE research grant in 2007 titled “studies on effect of host immunity on relapse rate and infectivity to mosquitoes in malaria using Plasmodium cynomolgi/Toque monkey system.  Granted by World Bank funded IRQUE project. Project period from 2007-2009.  Grant was Rs 150,000.00 and was conducted in Colombo.
  • IRQUE research grant in 2009 titled “Determination of clonality of parasites from Plasmodium cynomolgi relapse infections”.  Granted by World Bank funded IRQUE project. Project period from 2009-2010.  Grant was Rs 150,000.00 and was conducted in Colombo.
  • Co-investigator of the one-year research project, titled "Development of a real time quantitative PCR methods for analysis of vaccine protection using the Plasmodium cynomolgi model", ID A20219, awarded by the WHO in 1993.  Grant was USD 20,000.00 and was conducted in Kataragama and Colombo and was analysed in Nijmegen, Netherlands. 

RESEARCH COLLABORATIONS

  • Dr Sudath Peiris. Epidemiology Unit, Ministry of Health
  • Dr Geethani Galagoda,-Dept of Virology and Dr Sepali Gunawardena-Department of Immunology, Medical Research Institute, Colombo 8
  • Dr M C Weerasinghe, Department of Community Medicine, Faculty of Medicine, University of Colombo
  • Dr Shiroma Handunnetti,  Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo collaborated with me in Re-entry project, NSF project, NRC project and 2 IRQUE projects
  • Professor Richard Carter, ICAPB, Kings Buildings, University of Edinburgh, UK for the re-entry project, ID A00577.  NSF project, ID RG/2005/HS/14 and NRC project ID 05-66.  Collaboration with him still being continued.
  • Prof Richard Culleton, Head-Malaria Unit, University of Nagasaki, Japan for identification of strain-specific protective genes of malaria.
  • Professor Robert Sauerwein and Rob Hermsen, University of Nijmegen, The Netherlands for the project on "Development of a real time quantitative PCR methods for analysis of vaccine protection using the Plasmodium cynomolgi model"; ID A20219.
  • Professor Kazuyuki Tanabe, Osaka Institute of Technology, Japan is collaborating with me for a research project to study MSP1 and CSP polymorphisms of different strains of Plasmodium cynomologi parasite.
  • Prof Ananias Escalante, School of Life Sciences, Arizona State University, PO Box 874501, Tempe AZ 85287-4501, USA is collaborating in a project funded by Arizona State University to study prevalent malaria parasites in non-human primates and their evolutionary associations with human malaria parasites. 

 AWARDS/ SCHOLARSHIPS

  • Presidential award for scientific research for publications made in years 2005, 2007 and 2008.
  • NRC merit awards for publications made in 2010 and 2012
  • “Best paper presented in Basic Immunology” award for the paper titled “Studies on genetic composition of primary and relapse parasites of Plasmodium cynomolgi infections” when it was presented at Proceedings of the 2nd Biennial Scientific Sessions of the Allergy and Immunology Society of Sri Lanka 2004: B-2. 
  • “Best paper presented in Basic Immunology” award for the paper titled “Studies on strain-specific protective immunity in malaria using Plasmodium cynomolgi/ Macaca sinica model” at the Proceedings of the 3rd Biennial Scientific Sessions of the Allergy and Immunology Society of Sri Lanka, November 2006, B1, page 24.
  • “Best paper presented in Basic Immunology” award for the paper titled “Strain-specific protective immunity to  pre-erythrocytic stages of malaria parasite Plasmodium cynomolgi” when it was presented at the Proceedings of the 4th Biennial Scientific Sessions of the Allergy and Immunology Society of Sri Lanka 2009: B-1, Page 17.
  • “Best paper presented in Clinical Immunology” award for the paper titled “Low prevalence of IgG antibodies against measles, mumps and rubella in infants between 6-12 months of age in Colombo district, Sri Lanka” when it was presented at the Proceedings of the 7th Biennial Scientific Sessions of the Allergy and Immunology Society of Sri Lanka 2014: C-7, Page 35.
  • Awarded second place in best poster presented for the poster titled “Seroprevalence of measles, mumps and rubella antibodies in infants in Colombo district” presented at the 24th Annual scientific session of the Sri Lankan College of Microbiologists, 12th – 14th August 2015, pp20. 
  • Merit certificateawarded for the oral Presentation at the 4th YSF Symposium in 2015 for the study titled as “Degree of maternal transfer of antibodies against measles, mumps and rubella to newborns of pre- and post- vaccination era mothers”.
  • Best poster presented at the Scientific sessions of the College of Mricrobiologists, 2015
  • Research Training scholarship from the WHO/TDR in 1998 for the Molecular Biology training at University of Edinburgh, UK.
  • One year Research Training scholarship from the WHO/TDR in 1998 for the Molecular Biology/ Molecular Genetics training at University of Edinburgh, UK.

POSTGRADUATE RESEARCH SUPERVISION 

  • Primary Supervisor of the Ph D work of Dr WAWK Wijayalath at the Faculty of Medicine, University of Colombo.  Ph D titled “Studies on relapses and strain-specific protective immunity in Plasmodium cynomolgi infections in toque monkey, Macacva sinica”.  Effective Date of the Ph D was September 1, 2010.
  • Primary Supervisor of the M Phil/Ph D work of Ms Nadhikala Muthiah at the Faculty of Medicine, University of Colombo.  Ph D title “Study on measles, mumps and rubella antibody status in mothers & their newborn babies in Colombo district”.  Effective Date of registration in the Research and Higher Degrees Committee (RHDC) is 27th March 2013.
  • Primary Supervisor of the M Phil/Ph D work of Ms Rahini Mahendran at the Faculty of Medicine, University of Colombo.  M Phil title “Longitudinal study on effect of demographic, socioeconomic developmental and environmental factors on malaria incidence in a dry zone locality in Sri Lanka”.  Effective Date of registration in the Research and Higher Degrees Committee (RHDC) is 1st October 2014.
EXAMINATION/REVIEWING OF POSTGRADUATE RESEARCH DEGREES
  • External Examiner of the Ph D degree of Ms Afsheen Raza , September 2013, from Aga Khan University of Pakistan. Title of the Ph D thesis “Genetic diversity, drug resistance patterns and indicators of disease severity in Plasmodium vivax clinical isolates from Southern Pakistan
  • Examiner of M Sc degree of Ms Achini Rathnayake, December 2014, from Institute of Biochemistry Molecular Biology and Biotechnology, University of Colombo.  Title of the thesis “Effects of aqueous extracts of Anisomeles indica, Caesalpinia bonduc and Toddaliya asiatica on Pro-inflamatory mediators involved in pathogenesis of malaria
  • Examiner of M Sc degree of Ms H D A J C Harasgama, January 2014, from Institute of Biochemistry Molecular Biology and Biotechnology (IBMBB), University of Colombo.  Title of the thesis “Effects of the combined hot water extract of Coriandrum sativaum L. and Cosinium fenestratum L. on B-cell activation and expression of inducible nitric oxide synthase
  • Examiner of M Sc degree of Ms Dania Edwards, December 2012, from Institute of Biochemistry Molecular Biology and Biotechnology, University of Colombo.  Title of the thesis “Immunostimulatory activity of combined hot water extract of Coriandrum sativaum L. and Cosinium fenestratum L.
  • Examiner of M Sc degree of Ms S D Gnanarathnam, May 2008, from Institute of Biochemistry Molecular Biology and Biotechnology, University of Colombo.  Title of the thesis “Study of maternal insulin-like growth factor-1 levels in normal pregnancies and in pregnancies complicated by pregnancy-induced hypertention/pre-eclampsia
  • Examiner of M Sc degree of Ms HLC Nanayakkara, November 2008, from Institute of Biochemistry Molecular Biology and Biotechnology, University of Colombo.  Title of the thesis “Effects of aqueous extracts of Anisomeles indica, Caesalpinia bonduc and Toddaliya asiatica on Pro-inflamatory mediators involved in pathogenesis of malaria
  • Reviewer of the Ph D research work of Dr RMS Pimburage titled “Serological response following anti-rabies immunization of a canine population in a selected area of the Kalutara District” from 2010 to 2013, for the Research and Higher Degree Committee of the Faculty of Medicine, University of Colombo.

CONTRIBUTION TOWARDS NATIONAL DEVELOPMENT

  • Team member of the research colloquium on “elimination of malaria from, and prevention of its re-introduction to Sri Lanka: Defining operational research priorities’ which was held at National Blood Transfusion Centre on 10th December 2013.
  • Conducted a series of workshops for the Regional Medical Officers and Public Health Laboratory Technicians on identification of simian malaria parasites for the successful elimination of malaria from Sri Lanka.
  • Team member to develop national guidelines for the use of animals in research, under forum of ethics review committees of Sri lanka.
  • Assistant Secretary of the Allergy and Immunology Society of Sri Lanka for years 2008 – 2010 and the Treasurer from year 2011 till April 2015.
  • Contributed as a resource person in a series of workshops conducted on “identification of simian malaria parasites” for Public Health Laboratory Technicians of National Malaria Programme, 7th, 12th, 25th and 28th of November 2013.
  • Contributed as a resource person in the workshop conducted on “identification of simian malaria parasites” for Regional Malarial Officers of National Malaria Programme, 19th Nov 2013. 

MEMBERSHIP IN ACADEMIC AND PROFESSIONAL BODIES

  • Member of International Union of Immunological Societies (IUIS)
  • Member of Federation of Immunological Societies of Asia-Oceania (FIMSA)
  • Member of World Allergy Organization (WAO)
  • A member of the International Union of Immunological Societies (IUIS)
  • A Life Member of the Section A, Sri Lanka Association for the Advancement of Science (A xxxx). a Member of the Environment Committee for 3 years from 2001 to 2003
  • A Member of the Institute of Biology, Sri Lanka
  • A Founder and a Life Member of the Allergy and Immunology Society of Sri Lanka (L-009). Council Member and Assistant Secretary in years 2008, 2009 and 2010.  A Council Member and Treasurer from year 2011 to date
  • Sri Lanka representative for the Federation of Immunological Societies of Asia-Oceania (FIMSA) for year 2011- 2012
  • A Member of the Sri Lanka Society for Microbiology (0041)

PUBLICATIONS

1 Ph. D. Thesis

  • Parasite properties associated with pathogenesis of severe falciparum malaria (1997). Faculty of Medicine,University of Colombo,Sri Lanka. (Supervisors: Prof Kamini Mendis and Dr Shiroma Handunnetti; Examiners: Prof Marcel Hommel,UKand Prof Saroj Jayasinghe). 

2  Books

  • A chapter on “Laboratory safety” was written for the Booklet titled “An update on malaria”, which was Edited by Prof Deepika Fernando and Dr Sanath Senanayake in 2013.

3. Newspaper reports/ Letters to the Editors

  • Alles HK, Silva D de, Naotunne TDS, Pathirana PPSL, Jayasinghe S. Joint study by these authors was published under the title “Malaria parasite goes into hiding-inside you” in “Daily News”, December 28, 1994.
  • Alles HK, Silva D De, Mendis KN. Atypical presentation of malaria associated with chloroquine resistance (Acknowledgements to Sheriff MHR, Jayasinghe KAS, Naotunne, TDS, and Pathirana PPSL) 

4. Publications in peer reviewed journals

  1. Handunnetti S M, Jayasinghe S, Pathirana P P S L, Fernando R, Sheriff M H R,  and Mendis K N. Chloroquine and sulphadoxine‑pyrimethamine resistant Plasmodium falciparum  infection in Sri Lanka. Ceylon Medical Journal 1994:39;45‑46. PMID:8194148

  2. Handunnetti S M, Gunawardena D M, Pathirana P P S L, Ekenayake K, Weerasinghe S and Mendis K N. Features of recrudescent chloroquine-resistant Plasmodium falciparum infections confer a survival advantage on parasites, and have implications for disease control. Transactions of the Royal Society of Tropical Medicine and Hygiene1996:90;563-567.  doi: 10.1016/S0035-9203(96)90325-9

  3. Grech K, Martinelli A, Pathirana S, Walliker D, Hunt P & Carter R. Numerous, robust genetic markers for Plasmodium chabaudi by the method of Amplified Fragment Length Polymorphism.  Mol. Biochem. Parasitol. 2002:123;95-104.  doi:10.1016/S0166-6851(02)00142-1
  4. Pathirana S L, Alles H K, Perera M K, Bandara S, Phone-Kyaw M, Mendis K N and Handunnetti S M.  ABO blood group types and protection against severe Plasmodium falciparum malaria.  Annals of Tropical Medicine and Parasitology 2005:99 (2);119-124(6).  DOI: http://dx.doi.org/10.1179/136485905X19946
  5. Tanabe K, Escalante A, Sakihama N, Honda M, Arisue N, Horii T, Culloton R, Hayakawa T, Hashimoto T, Longacre S, Pathirana S, Handunnetti S, Kishino H.  Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites.  Mol. Biochem. Parasitol. 2007:156; 74-79.    doi:10.1016/j.molbiopara.2007.07.002
  6. Wijayalath WAWK, Cheesman S, Rajakaruna J, Handunnetti SM, Carter R, Pathirana P P S L. Evidence for strain-specific protective immunity against blood-stage parasites of Plasmodium cynomolgi in toque monkey.  Parasite Immunology. 2008:30;630-636. DOI: 10.1111/j.1365-3024.2008.01065.x
  7. Hiromi Sawai, Hiroto Otani, Nobuko Arisue, Nirianne Palacpac, Sisira Pathirana, Shiroma Handunnetti, Leonardo de Oliveira Martins, Satoru Kawai, Hirohisa Kishino, Toshihiro Horii, and Kazuyuki Tanabe. Lineage-specific Positive Selection at the Merozoite Surface Protein 1 (msp1) Locus of Plasmodium vivax and related Simian Malaria Parasites. BMC Evolutionary Biology 2010, 10:52.  doi:10.1186/1471-2148-10-52
  8. S. L. Pathirana, K. Ekenayake, R. J. Howard, K. N. Mendis and S. M. Handunnetti. Cytoadherence and its association with clinical disease in Plasmodium falciparum infections in Sri Lanka. J. Natn. Sci. Foundation Sri Lanka 2010:38(4);233-240.  URL - file:///C:/Users/Hello/Downloads/2650-9200-1-PB.pdf
  9. Wathsala Wijayalath, Sandie Cheesman, Jagath Rajakaruna, Ssudath Weerasinghe, Gamini Kapilananda, Kamal Gamage, Kamal Perera,  Shiroma Handunnetti, Richard Carter and Sisira Pathirana. Strain specific protective immunity induced by pre-erythrocytic infection of toque monkeys with Plasmodium cynomolgi.  Malaria Journal 2010, 9 (Suppl 2):P58 –S2.  doi:10.1186/1475-2875-9-S2-P58
  10. Wathsala Wijayalath, Sandra Cheesman, Kazuyuki Tanabe, Shiroma Handunnetti, Richard Carter, Sisira Pathiarana. Strain-specific protective effect of the immunity induced by live malarial sporozoites under chloroquine cover. PLoS ONE.  2012, 7(9) e45861:1-7.  DOI: http://dx.plos.org/10.1371/journal.pone.0045861
  11. M. K. Perera; N. P. Herath; S. L. Pathirana; M. Phone-Kyaw; H. K. Alles; K. N. Mendis; S. Premawansa; S. M. Handunnetti. Association of high plasma TNF-alpha levels and TNF-alpha/IL-10 ratios with TNF2 allele in severe P. falciparum malaria patients in Sri Lanka.  Pathogens and Global Health, 2013, 107(1); 21-29(9). DOI: http://dx.doi.org/10.1179/2047773212Y.0000000069

6. Abstracts published in conference proceedings

      6.1 International:

  1. Handunnetti S M, Mendis K N, Gunewardena D M, Pathirana P P S L (1996).  Recrudescent chloroquine-resistant Plasmodium falciparum parasites have a survival advantage.  XIV International congress for Tropical Medicine and Malaria, Nagasaki, Japan. Pp169, O-07.
  2. Pathirana P P S L, Alles H K, Perera M K, Mendis K N and Handunnetti S M (1997). Association between ABO blood groups and protection against severe and complicated Plasmodium falciparum malaria.  Proceedings of the 2nd Global Meet on Parasitic Diseases. Hyderabad, India. pp187-188 .
  3. Handunnetti S M, Pathirana P P S L, Howard R J, Mendis K N (1997).  Adherence of Plasmodium falciparum-infected erythrocytes to ICAM-1: A marker of parasite virulence. Proceedings of the 2nd Global Meet on Parasitic Diseases. Hyderabad, India. pp 213-214.
  4. Wathsala Wijayalath, Sandie Cheesman, Jagath Rajakaruna, Sudath Weerasinghe, Gamini Kapilananda, Kamal Gamage, Kamal Perera, Shiroma Handunnetti, Richard Carter, Sisira Pathirana. Strain specific protective immunity induced by pre-erythrocytic infection of toque monkeys with Plasmodium cynomolgi. Proceedings of the Parasite to Prevention:Advances in understandingof malaria. October 20 – 22, 2010 Edinburgh UK (poster).Appeared in Malarial Journal 2010, 9 (Suppl 2):P58 doi:10.1186/1475-2875-9-S2-P58.
  5. Jayasinghe JASSK, Jayasekera NM, Jayasekera DP, Pathirana S. Pattern of fractures in road traffic accident victims admitted to the accident service wards of the national hospital of Sri Lanka. Presented in Medcon international conference from 11-14 April 2013, at UCMS, New Delhi, India.  Published in Indian Journal of Medical Specialities 2013. 4(2); 157-158.
  6. Sisira Pathirana, Katrina Grech and Richard Carter (1999). Molecular markers to identify strain-specific targets of protective immunity in Plasmodium chabaudi.  Annual Meeting of the Scottish Universities Molecular Parasitologists (SUMP VII). Kindrogan, Scotland (Abstract 9).
  7. K Grech, A Martinelli, S Pathirana, P Hunt and R Carter (2000). Amplified fragment length polymorphisms (AFLP) to construct a high-resolution genetic linkage map in Plasmodium chabaudiProceedings of the New challenges in tropical medicine and Parasitology (Oxford 2000, a joint meeting organized by The Royal Society of Tropical Medicine and Hygiene, British Society for Parasitology and The American Society of Tropical Medicine and Hygiene). pp 120.
  8. N Muthiah, PPSL Pathirana, S Peiris, SM Handunnetti, GCS Galagoda.Prevalence of maternally transferred anti-measles antibodies in Sri Lankan infants. 33rd Annual Meeting of the European Society for Paediatric Infectious Diseases, Germany, 12th – 16th May 2015, pp64.

      6.1 National:

  1. Handunnetti S M, Pathirana P P S L, Ekenayake K, Howard R J, Mendis K N. In vitro rosetting and micro-agglutination properties of Plasmodium falciparum‑ infected erythrocytes. Proceedings of the Sri Lanka Asso­ciation for the Advancement of Science. 1992, 48: 1.
  2. Pathirana P P S L, Ekenayake K, Perera K L R L, Howard R J, Mendis K N, Handunnetti S M. Adherence properties of Sri Lankan Plasmodium falciparum isolates to endothelial cell receptor CD36. Proceedings of the Sri Lanka association for the Advancement of Science. 1993, 49:16.
  3. Handunnetti S M, Pathirana P P S L, Ekenayake K, Kapilananda G M, Perera K L R L, Mendis K N. Drug resistance and clinical immunity in Plasmodium falciparum infections among hospital admission in Colombo, Sri Lanka. Proceedings of the Sri Lanka association for the Advancement of Science. 1993, 49:14.
  4. Wattavidanage J, Perera K L R L, David P H, Carter R, Ranford‑Cartwright L, Kapilananda G M, Pathirana P P S L, Handunnetti S M, Mendis K N, Premawansa W S. Genetic heterogeneity of Plasmodial genes in Sri Lankan isolates as detected by the Polymerase Chain Reaction. Proceedings of the Sri Lanka association for the Advancement of Science. 1993, 49: 20.
  5. Alles H K, Silva D De, Naotunne T D S, Pathirana P P S L, Jayasinhe S, Sheriff M H R, Mendis K N. Atypical presentation of malaria in Sri Lanka Associated with chloroquine resistance. Proceedings of the 49th Annual Session of the Sri Lanka Association for the Advancement of Science. 1994, 50: 6.  
  6. Pathirana P P S L, Ekenayake K, Weerasinhe S, Alles H K, Carter R, Mendis K N, Handunnetti S M. Enhancement of cytoadherence of Plasmodium falciparum-infected erythrocytes to CD36 by malarial paroxysm plasma. Proceedings of the Sri Lanka association for the Advancement of Science. 1994, 50: 24.
  7. Pathirana P P S L, Ekenayake K, Alles H K, Bandara S, Mendis K N and Handunnetti S M. Regulation of adherence of Plasmodium falciparum-infected erythrocytes to ICAM-1 by plasma from cerebral malaria patients. Proceedings of the Sri Lanka Association for the Advancement of Science. 1996, 52: 25-26.
  8. Pathirana P P S L, Ekenayake K, Mendis K N and Handunnetti S M. Cytoadherence properties of Plasmodium falciparum-infected erythrocytes in relation to severity of clinical disease and parasite density in uncomplicated malaria in Sri Lanka. Proceedings of the Sri Lanka Association for the Advancement of Science. 1996, 52: 26.
  9. Pathirana P P S L, Alles H K, Perera M K, Myat Phone-Kyaw, Ekenayake K, Bandara S, Wijesinhe U, Somatileke D, Wimalasena C, Abeynayake S, Mendis K N and Handunnetti S M.  Association between ABO blood groups and disease severity in Plasmodium falciparum malaria. Proceedings of the Sri Lanka Association for the Advancement of Science. 1997, 53: 6.     
  10. M K Perera, S D Abeynayake, M Phone-Kyaw, S Bandara, H Alles, N Fernando, C Wimalesena, S L Pathirana, S Premawansa, Kamini Mendis, S M Handunnetti.  Plasma cytokine levels in severe-complicated Plasmodium falciparum malaria. Proceedings of the Sri Lanka Association for the Advancement of Science. 1998, 54: 32.
  11. Sisira Pathirana, Katrina Grech and Richard Carter. Molecular markers to identify genes, which code targets of strain-specific protective immunity in Plasmodium chabaudi. Proceedings of the Sri Lanka Association for the Advancement of Science. 2000, 56: 6.
  12. R A Munasinghe, P P S L Pathirana, S A A Jagadeesh, M Ileperuma, K L R L Perera, S M Handunnetti, S Premawansa. Auto-agglutination abilities of Plasmodium falciparum parasite isolates from severe complicated and uncomplicated P. falciparum infections. Proceedings of the Sri Lanka Association for the Advancement of Science. 2001, 57:18.
  13. S M Handunnetti, S Weerasinghe, C Ameratunga, S L Pathirana, J Rajakaruna, K L R L Perera, K Gamage, K Perera, I Holm, and S Longacre. Immunogenecity and protective efficacy of two new vaccine formulations based on MSP1-P19 of Plasmodium cynomolgi. Proceedings of the Joint Academic Sessions, Faculties of Science and Medicine of the University of Colombo. 2004, Page 15.
  14. P P S L Pathirana, Liselotte Walters, Sudath Weerasinghe, Shirly Longacre, Robert Sauerwein, Shiroma Handunnetti and C C Hermsen. Development of Real Time Quantitative PCR (RTQ PCR) method for analysis of vaccine protection using Plasmodium cynomolgi malaria model.  Proceedings of the Joint Academic Sessions, Faculties of Science and Medicine of the University of Colombo. 2004, Page 16.
  15. W A W K Wijayalath, J Rajakaruna, K Gamage, K Perera, K L R L Perera, C Ameratunga, N Sakihama, K Tanabe, S Cheesman, R Carter, S M Handunnetti and P P S L Pathirana. Are relapse infections of Plasmodium cynomolgi, clones of primary infections? Proceedings of the Joint Academic Sessions, Faculties of Science and Medicine of the University of Colombo. 2004, Page 23.
  16. I C Perera, P P S L Pathirana, G M Kapilananda, R A Munasinghe, S M Handunnetti and S Premawansa. Inhibitory effects on parasite cytoadherence by sera from Plasmodium falciparum infected Sri Lankan patients.  Proceedings of the Sri Lanka Association for the Advancement of Science.2004, Page 28.
  17. P P S L Pathirana, Liselotte Walters, Sudath Weerasinghe, Shirly Longacre, Robert Sauerwein, Shiroma Handunnetti and C C Hermsen. Development of Real Time Quantitative PCR (RTQ PCR) method for analysis of vaccine protection using Plasmodium cynomolgi malaria model.  Proceedings of the 2nd Annual Sessions of Allergy and Immunology Society of Sri Lanka. 2004, B-3.
  18. W A W K Wijayalath, J Rajakaruna, K Gamage, K Perera, K L R L Perera, C Ameratunga, N Sakihama, K Tanabe, S Cheesman, R Carter, S M Handunnetti and P P S L Pathirana. Studies on genetic composition of primary and relapse parasites of Plasmodium cynomolgi infections.  Proceedings of the 2nd Annual Sessions of Allergy and Immunology Society of Sri Lanka. 2004, B-2.
  19. I. C. Perera, R.A. Munasinghe, S. Pathirana, M. K. Perera, M. Ileperuma, T. Nadaraja, G. M. Kapilananda, G. Premawansa, S. M. Handunnetti and S. Premawansa. Cytoadherence and its inhibition of Plasmodium falciparum parasites from Sri Lankan patients to human endothelial receptors of CD36 and ICAM-1. Proceedings of the 2nd Annual Academic Sessions of the Allergy and Immunology Society of Sri Lanka, November 2004, B-8.
  20. 20.  D C S Gunasekara, P P S L Pathirana, I C Perera, R A Munasinghe, M G M Kapilananda, S Premawansa. 2005.  Agglutination properties of Plasmodium falciparum parasites and their associations with cytoadherence and disease severity. Proceedings of the 25th Annual Academic Sessions of the Institute of Biology, Sri Lanka. 2005, 33.
  21. Varuni Munasinghe, Inoka Perera, Sisira Pathirana, Wathsala Wijayalath, Anjanie Munasinghe, Dulip Gunasekara and Sunil Premawansa.  Cytoadherence of Plasmodium falciparum Sri Lankan parasite isolates to human endothelial receptors at two different temperatures. Proceedings of the 25th Annual Academic Sessions of the Institute of Biology, Sri Lanka. 2005.
  22. WAWK Wijayalath, S Cheesman, J Rajakaruna, K Gamage, K Perera, KLRL Perera, R Carter, SM Handunnetti, PPSL Pathirana. 2006.  Studies on strain-specific protective immunity in malaria using Plasmodium cynomolgi/ Macaca sinica model. Proceedings of the 3rd Annual Academic Sessions of the Allergy and Immunology Society of Sri Lanka, November 2006, B1, page 24.
  23. Jayawardena KH, Sooriya Arachchi NN, Wijayalath WAWK, Pathirana PPSL. Dynamics of host immunity in relation to Plasmodium cynomolgi relapse infections in toque monkey (Macaca sinica). Fifth Annual Academic Sessions, The Open University of Sri Lanka 2008; 102-104
  24. WAWK Wijayalath, S Cheesman, J Rajakaruna, S Weerasinghe, GMG Kapilananda, K Gamage, K Perera, SM Handunnetti, R Carter and PPSL Pathirana. “Strain-specific protective immunity to  pre-erythrocytic stages of malaria parasite Plasmodium cynomolgi”.  Proceedings of the 4th Biennial Scientific Sessions of the Allergy and Immunology Society of Sri Lanka, July 2009, B1, page 17.
  25. WAWK Wijayalath, S Cheesman, J Rajakaruna, S Weerasinghe, GMG Kapilananda, K Gamage, K Perera, V K Kandaudahewa, SM Handunnetti, R Carter and PPSL Pathirana. “Immunization by live malarial sporozoites: inoculation under chloroquine treatment is not protective against malarial relapses”.  Proceedings of the 5th Biennial Scientific Sessions of the Allergy and Immunology Society of Sri Lanka, July 2010, B1, page 13.
  26. Wathsala Wijayalath, Sandie Cheesman, Jagath Rajakaruna, Sudath Weerasinghe, Gamini Kapilananda, Kamal Gamage, Kamal Perera, Shiroma Handunnetti, Richard Carter, Sisira Pathirana. Strain specific protective immunity induced by pre-erythrocytic infection of toque monkeys with Plasmodium cynomolgi. Proceedings of the Parasite to Prevention:Advances in understandingof malaria. October 20 – 22, 2010 Edinburgh UK (poster).Appeared in Malarial Journal 2010, 9 (Suppl 2):P58 doi:10.1186/1475-2875-9-S2-P58.
  27. Pathirana S, Wijayalath W, Cheesman S, Ranasinghe T, Rajakaruna J, Weerasinghe S,  Kapilananda G, Gamage K, Perera K, Handunnetti S, Carter R.. Strain specific protective immunity induced by infection with pre-erythrocytic stages of Plasmodium cynomolgi.in toque monkeys.  Proceedings of the University of Colombo research forum June 28-29, 2011.  PP3, Pg 238-239.
  28. M Nadhikala, PPSL Pathirana, SM Handunnetti, Sudath Peiris and GCS Galagoda. Low prevalence of IgG antibodies against measles, mumps and rubella in infants between 6-12 months of age in Colombo district, Sri Lanka. Proceedings of the 7th Biennial Scientific Sessions of the Allergy and Immunology Society of Sri Lanka 2014: C-7, Page 35.
  29. M Nadhikala, PPSL Pathirana, SM Handunnetti, Sudath Peiris and GCS Galagoda.  Study on passive transfer of maternal IgG antibodies against measles, mumps and rubella from mothers to infants. [Proceedings of the 34th annual sessions of the Institute of Biology 2014, 2-14, Page 54.
  30. M Nadhikala, PPSL Pathirana, SM Handunnetti, Sudath Peiris and GCS Galagoda. Degree of maternal transfer of anti-measles antibodies to newborns of vaccinated and naturally immune mothers. Proceedings of the Annual Scientific Sessions of the Sri Lanka Society for Microbiology, 2014. Pg 2, Volume 2.
  31. Rajitha Sanjeewa and Sisira L Pathirana. Factors affecting compliance to self-management therapeutic exercises in osteoarthritis patients in Sri Lanka.  Proceedings of the 1st Ruhuna International Science and Technology Conference (RITSCON) organized by the Faculty of Science, University of Ruhuna, January 22-23 2014. Page xx.
  32. PP Rubasinghe and PPSL Pathirana. Efficasy of Physiotherapy management and ayurvedic management of Kee joint osteoarthritis.  Proceedings of the 2nd Ruhuna International Science and Technology Conference (RITSCON) organized by the Faculty of Science, University of Ruhuna, January 22-23 2015. Page 48.
  33. M Nadhikala, PPSL Pathirana, Sudath Peiris, SM Handunnetti, GCS Galagoda.  Degree of maternal transfer of antibodies against measles, mumps and rubella to newborns of pre- and post- vaccination era mothers. 4th YSF Symposium, 23rd January 2015. Page 128-131.
  34. M Nadhikala, PPSL Pathirana, Sudath Peiris, SM Handunnetti, GCS Galagoda.  Passive transfer and decay of maternally transferred IgG antibodies against measles, mumps and rubella in infants in Colombo district, Sri Lanka. 7th annual scientific sessions, Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo.  21st May 2015.  OP12, Page 22.
  35. Wasundara PR, Pathirana SL and Senarath U.  Risk factors and musculoskellital disabilities associated with cervical spondylosis patients attending the physiotherapy clinic of Base Hospital, Horana.  128th Anniversary International Medical Congress, 6th to 8th July 2015. OP 025, pp 129-130.
  36. Nadhikala M, Pathirana PPSL, Peiris S, Handunnetti SM, Galagoda GCS. Passive transfer and decay of maternally transferred IgG antibodies against measles, mumps and rubella in infants in Colombo district, Sri Lanka.7th Annual scientific session of Institute of Biochemistry, Molecular Biology and Biotechnology, 21st May 2015, pp22.
  37. M Nadhikala, PPSL Pathirana, Sudath Peiris, SM Handunnetti, GCS Galagoda.  Seroprevalence of measles, mumps and rubella antibodies in infants in Colombo district. 24th Annual scientific session of the Sri Lankan College of Microbiologists, 12th – 14th August 2015, pp20 (Awarded second place in best poster presented).